Comparative study of antibody titers produced against two BHK rabies vaccines in field trial experimental condition in dogs by RFFIT

نویسندگان

  • A. Fayaz WHO Collaboration Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
  • A. R. Bahonar Department of Clinical Sciences and Research Center for Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  • A. R. Janani WHO Collaboration Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
  • A. R. Zavarei WHO Collaboration Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
  • A.3 Aliyari BSc in Veterinary Medicine Lab. Technology, Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  • I. Rad Ph.D. Student in Biophysics, Research Institute of IBB, University of Tehran, Tehran, Iran
  • M. A. Rad Department of Clinical Sciences and Research Center for Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  • M. Taghikhani WHO Collaboration Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
  • N. Eslami BSc in Medicine Lab. Technology, WHO Collaboration Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
  • N. Howaizi BSc in Medicine Lab. Technology, WHO Collaboration Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
  • P. Biglari BSc in Medicine Lab. Technology, WHO Collaboration Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
  • S. J. Aldavood Department of Clinical Sciences and Research Center for Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  • S. Simani WHO Collaboration Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran
  • Sh. Jamshidi Department of Clinical Sciences and Research Center for Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
  • Sh. Shoaei Department of Clinical Sciences and Research Center for Zoonoses, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
چکیده مقاله:

Rabies is acutely fatal encephalitis caused by a neurotropic virus. This virus belongs to the family ofRhabdoviridae and genus of Lyssavirus. The virus is almost always transmitted to human through infectedmammalian saliva. Rabies is inoculated to a wound by an infected animal bite. Since infection is establishedin the CNS, the outcome is almost always fatal. According to the outstanding role of vaccination againstrabies in animals, as well as post-exposure treatment regimen in human, production of cell-cultured rabiesvaccine is the most common interest of researchers. Two BHK-rabies vaccines, one made in the PasteurInstitute of Iran and two in Schering-Plough Animal Health of Madrid, Spain have been tested on 12 dogsdivided into two groups. Sera were taken monthly over 18 months. To evaluate the titer of the rabiesneutralizing antibody, these sera were analyzed by the rapid fluorescence focus inhibition test (RFFIT) in the end of each month. Both study groups showed a sufficient immunogenic response without any significant difference at least one year after first vaccination. With respect to the effective immunization of rabies vaccines, their annual injections would be sufficient. According to the results, at the end of the study (18th month) serum titer in only one dog (No. 7) was less than protective level. Two animals in group one (No. 2 and No. 5) also had serum titers less than protective level. Mean of post vaccination antibody titer were not different in either groups (P=0.35).

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comparative study of antibody titers produced against two bhk rabies vaccines in field trial experimental condition in dogs by rffit

rabies is acutely fatal encephalitis caused by a neurotropic virus. this virus belongs to the family ofrhabdoviridae and genus of lyssavirus. the virus is almost always transmitted to human through infectedmammalian saliva. rabies is inoculated to a wound by an infected animal bite. since infection is establishedin the cns, the outcome is almost always fatal. according to the outstanding role o...

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عنوان ژورنال

دوره 11  شماره 3

صفحات  279- 282

تاریخ انتشار 2010-09-20

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